Negative Staining: Sample Preparation, Advantages, and Protocols

What is Negative Staining? Negative staining is a specialized technique used in electron microscopy to prepare samples by creating a reverse contrast image. It is primarily used to observe particulate matter or biological macromolecules, this method involves spreading a sample onto a grid and applying a metal salt stain. This process results in the stain […]

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Cryo-EM Single Particle Analysis (SPA): Unveiling the Structural Mysteries of Biomolecules

What is Cryo-EM Single Particle Analysis (SPA)? Cryo-Electron Microscopy (Cryo-EM) is a technique that uses an electron microscope to observe samples, with the key feature being its ability to image samples in their native state at cryogenic temperatures, thus avoiding structural alterations that might occur during traditional sample preparation. Cryo-EM was initially used to study […]

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Negative Staining: Sample Preparation, Advantages, and Protocols

Cryo-EM Single Particle Analysis (SPA): Unveiling the Structural Mysteries of Biomolecules